Rick Kraemer

Fredric B. Kraemer, MD, Gerald M. Reaven MD Professor in Endocrinology, Department of Medicine, Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine

Research Description: Dr. Kraemer’s research career began with a focus on insulin resistance and glucose metabolism during which he contributed to some of the early studies utilizing insulin clamps and examining the effects of differences in the sources of carbohydrates on insulin and glucose responses in humans. Although continuing to be interested in insulin and glucose metabolism, the major focus of most of his research has been directed at understanding various aspects of cellular lipid metabolism. These studies have primarily focused on adipose tissue metabolism and, particularly, on lipid droplet formation and the regulation of lipid droplet hydrolysis leading to the release of fatty acids. He has had longstanding, productive collaborations with multiple members of SDRC. Dr. Kraemer also serves on the SDRC Executive Committee and as Director of the SDRC Pilot and Feasibility Award Program.

Selected relevant publications (Stanford DRC members in BOLD):

  1. Han L, Bittner S, Dong D, Cortez Y, Bittner A, Chan J, Umar M, Shen WJ, Peterson RG, Kraemer FB, Azhar S. Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes. Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165688. doi: 10.1016/j.bbadis.2020.165688. PMID: 31987840. 

  2. Singh AB, Dong B, Kraemer FB, Liu J. FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR-B1-deficient mice fed a high-fat and high-cholesterol diet. Physiol Rep. 2020 Mar;8(5):e14387. doi: 10.14814/phy2.14387. PMID: 32170842; PMCID: PMC7070099. 

  3. Azhar S, Bittner S, Hu J, Shen WJ, Cortez Y, Hao X, Han L, Lagerstedt JO, Kraemer FB, Johansson JO. Novel ABCA1 peptide agonists with antidiabetic action. Mol Cell Endocrinol. 2019 Jan 15;480:1-11. doi: 10.1016/j.mce.2018.09.011. PMID: 30290217; PMCID: PMC6626528. 

  4. Wang W, Yan Z, Hu J, Shen WJ, Azhar S, Kraemer FB. Scavenger receptor class B, type 1 facilitates cellular fatty acid uptake. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158554. doi: 10.1016/j.bbalip.2019.158554. PMID: 31678516; PMCID: PMC6957692.